Elsevier

Toxicon

Volume 21, Issue 6, 1983, Pages 903-907
Toxicon

Short communication
Interaction of Clostridium difficile toxins and mouse hepatic microsomes

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Abstract

M. Ehrich. Interaction of Clostridium difficile toxins and mouse hepatic microsomes. Toxicon21, 903–907, 1983. — Intraperitoneal administration of toxins of Clostridium difficile to mice resulted in loss of hepatic cytochrome P450 and peroxidation of microsomal lipids. Pretreatment with the microsomal enzyme inducer β-napthoflavone partially alleviated these effects and increased survival time of intoxicated animals.

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