Terpenoids—CVII: The structure of nardostachone
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Cited by (13)
Sesquiterpenoids with various carbocyclic skeletons from Nardostachys chinensis with nitric oxide inhibitory activity
2021, Phytochemistry LettersCitation Excerpt :The 95% aqueous ethanol extract of the roots and rhizomes of N. chinensis was subjected to column chromatography over macroporous resin, Sephadex LH-20, and C18-ODS and then purified by preparative HPLC to yield 21 sesquiterpenoids (1-21). The known compounds were identified as eudesmane K (4) (Demole and Enggist, 1983), 1-hydroxylaristolone (5) (Chen et al., 2017), debilon (6) (Itokawa et al., 1993), nardostachone (7) (Sastry et al., 1967), 3-Oxokanshone H (8) (Chen et al., 2017), 1(10)-aristolen-2-one (9) (Dellar et al., 1994), (-)-(14β,15β)-aristolone (10) (Furusawa et al., 2006), nardoaristolone B (11) (Liu et al., 2013), kanshone F (12) (Tanitsu et al., 2002), narchinol A (13) (Hikino et al., 1972), desoxo-nachinol (14) (Itokawa et al., 1993), kanshone A (15) (Itokawa et al., 1993), nardosinonediol (16) (Itokawa et al., 1993), ardosinone (17) (Itokawa et al., 1993), nardonoxide (18) (Luo et al., 1987), kanshone E (19) (Anjana et al., 1988), isonardosmone (20) (Anjana et al., 1988), and kanshone N (21) (Yoon et al., 2018) (Fig. S1), based on comparison of their spectroscopic data with the literature values. The structures of the new compounds 1-3 were elucidated by analysis of HRESIMS, UV, IR, 1D/2D NMR, and circular dichroism data.
A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys
2021, Journal of EthnopharmacologyNardostachys jatamansi (D.Don) DC.: An invaluable and constantly dwindling resource of the Himalayas
2020, South African Journal of BotanyCitation Excerpt :N. jatamansi rhizomes are extensively exploited for the preparation of drugs due to the presence of biologically active and industrially important phytochemicals such as coumarins, alkaloids, lignans, neoloignans, sesquiterpenes, sesquiterpenoids and their derivatives, with a wide range of biological properties (Table 6) (Bagchi et al., 1990; 1991a, b; Chatterjee et al., 2005; Saroya, 2011; Purnima et al., 2015). Other major compounds also present in underground tissues include actinidine (alkaloid), jatamansin and jatamansinol (coumarins), nardostachone, valeranone, jatamansinone, nardosinone, jatamol A and jatamol B (sesquiterpenoids) (Zinzius, 1961; Biswas, 1963; Sastry et al., 1967; Bagchi et al., 1991b; Singh et al., 2013; Monga and Kumar, 2013; Bose et al., 2019; Dhiman and Bhattacharyya, 2020). Some important phytochemicals derived from N. jatamansi are listed in Fig 4.
Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities of harnessing the untapped medicinal plant from the Himalayas
2020, Journal of EthnopharmacologyCitation Excerpt :Jatamanshic acid, a new bi-cyclic sesquiterpene was also isolated and its chemical structure was established on the basis of chemical degradation, NMR, IR and UV absorption patterns (Chaudhry et al., 1957). Calarenol, a monoethynoid tricyclic tertiary alcohol (C15H24O), nardostachone - a ketonic compound having the molecular formula, C15H22O (Sastry et al., 1967), spirojatamol - a sesquiterpenoid (Bagchi et al., 1990) and nardostachysin - a terpenoid ester (Chatterjee et al., 2000) are the other compounds reported from the plant. A sesquiterpene acid, nardin, and a pyranocoumarin were also isolated from the rhizomes, and their chemical structures established using spectral studies (Chatterjee et al., 2005).
Phylogenetic implications of an expanded valepotriate distribution in the Valerianaceae
1998, Biochemical Systematics and EcologyFurther studies relating to the structure of nardostachone
1977, Tetrahedron Letters
Communication No. 980.