Additive effects of forgetting and fornix transection in the temporal gradient of retrograde amnesia
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Cited by (43)
A computational theory of hippocampal function, and tests of the theory: New developments
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :This raises the issue of the possible gradient of retrograde amnesia following hippocampal damage, and of whether information originally hippocampus-dependent for acquisition gradually becomes “consolidated” in the neocortex and thereby become hippocampus-independent over time (Debiec et al., 2002; McGaugh, 2000). The issue of whether memories stored some time before hippocampal damage are less impaired than more recent memories, and whether the time course is minutes, hours, days, weeks or years is a debated issue (Gaffan, 1993; Squire, 1992). ( In humans, there is evidence for a gradient of retrograde amnesia; in rats and monkeys, hippocampal damage in many studies appears to impair previously learned hippocampal-type memories, suggesting that in these animals, at least with the rather limited numbers of different memories that need to be stored in the tasks used, the information remains in the hippocampus for long periods).
Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents
2011, Current Opinion in NeurobiologyCitation Excerpt :The simpler idea that there are multiple memory storage sites, each with its own acquisition and consolidation process, was widely rejected in the mid-1990s, because of influential experiments with nonhuman animals (for example [8,9]) showing that HPC damage disrupted recent memories much more than more remote memories formed by the same learning episodes. Yet, demonstrations were in hand of equivalent disruption of recent and remote memories, referred to as flat gradients [10,11]. Reports with human patients appeared where even remote memories seemed to be impaired.
The volumes of the fornix in schizophrenia and affective disorders: A post-mortem study
2008, Psychiatry Research - NeuroimagingCitation Excerpt :However, only one post-mortem study by Chance et al. (1999) considered the cross-sectional areas and the total fiber number of the fornix in schizophrenia. The fornix plays a major role in functions that are assumed to be disturbed in schizophrenia such as memory retrieval (Gaffan, 1993; Calabrese et al., 1995), verbal memory (Calabrese et al., 1995; McMackin et al., 1995), spatial memory (Gaffan, 1994; Parker and Gaffan, 1997; Murray et al., 1998; Galani et al., 2002; Buckley et al., 2004), increased motor activity (Weiner et al., 1998) and transitive inference (Dusek and Eichenbaum, 1997). Morphologically, near the splenium of the corpus callosum the fimbria of the hippocampus becomes the crus of the fornix which sends fibers forward at the inferior edge of the septum pellucidum to the interventricular foramen.
A computational theory of hippocampal function, and empirical tests of the theory
2006, Progress in NeurobiologyCitation Excerpt :This raises the issue of the possible gradient of retrograde amnesia following hippocampal damage, and of whether information originally hippocampus-dependent for acquisition gradually becomes “consolidated” in the neocortex and thereby becomes hippocampus-independent over time (Debiec et al., 2002; McGaugh, 2000). The issue of whether memories stored some time before hippocampal damage are less impaired than more recent memories, and whether the time course is minutes, hours, days, weeks or years is a debated issue (Gaffan, 1993; Squire, 1992). ( In humans, there is evidence for a gradient of retrograde amnesia; in rats and monkeys, hippocampal damage in many studies appears to impair previously learned hippocampal-type memories, suggesting that in these animals, at least with the rather limited numbers of different memories that need to be stored in the tasks used, the information remains in the hippocampus for long periods.)
Consolidation and the hippocampal complex revisited: In defense of the multiple-trace model
1998, Current Opinion in Neurobiology