Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline
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Cited by (81)
Antidepressants as Analgesics
2013, Practical Management of Pain: Fifth EditionAntidepressants as Analgesics
2013, Practical Management of Pain: Fifth EditionEffect of amitriptyline on glycinergic transmission in rat medullary dorsal horn neurons
2012, Brain ResearchCitation Excerpt :For example, amitriptyline blocks various subtypes of VDNCs, including TTX-sensitive and TTX-resistant Na+ channels, in a state-dependent manner in sensory neurons (Bräu et al., 2001; Dick et al., 2007; Hur et al., 2008). Other mechanisms might include the inhibition of norepinephrine and/or serotonin reuptake in the spinal dorsal horn (Taiwo et al., 1985), the inhibition of various ligand-gated ion channels, such as nicotinic acetylcholine receptors (Freysoldt et al., 2009), NMDA receptors (Reynolds and Miller, 1988), P2X receptors (Nagata et al., 2009; but see also Sim and North, 2010), and the direct and indirect effects on μ-opioid receptors (Hamon et al., 1987; Isenberg and Cicero, 1984). In the present study, we found that amitriptyline at ≥ 10 μM concentrations significantly enhanced spontaneous glycine release onto medullary dorsal horn neurons.
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation
2011, Pharmacological ResearchCitation Excerpt :Although this study cannot rule out the influence of other neurotransmitters mediating MAE, such as noradrenaline or dopamine, which can also be stimulated by morphine [29,31] and regulated by 5-HT [32,33], there is good evidence that kappa receptors play a crucial role in nociception. This action could be mu-opioid receptor independent [8–34] and related to 5-HT modulation [35,36]. Our results point at new potential therapeutic applications of kappa-opioid receptor ligands and encourage new efforts in the development of ligands for these receptors as potential analgesics [37,38].