Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse
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Cited by (63)
Tests of unconditioned anxiety - Pitfalls and disappointments
2014, Physiology and BehaviorCitation Excerpt :It is considered an exploratory behavior [63,135], an orienting response [79], a means of sampling or scanning the environment [1,264], or a marker of environmental novelty [181,236]. Like other ethological parameters, rearing has been used as an indicator of anxiety in the EPM [129,235,330], the LDB [84,89,235] and the OF [63,229]. Reductions in the number of rearing has been interpreted as heightened anxiety responses [29,329,331,359], and like grooming, it has been reported to occur mostly in the enclosed areas of the EPM [6,65,129,275,330,331] and against the walls and in the corners of the OF [63,65,74,229].
Use of the light-dark box to compare the anxiety-related behavior of virgin and postpartum female rats
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Many GABAA receptor modulators inconsistently affect anxiety in male rats (Millan, 2003) and such effects might depend on the particular behavioral tests used (Nazar et al., 1997). For example, FG-7142 can be intrinsically anxiogenic in male mice, but not when assessed with a light–dark box (Crawley et al., 1984). Similarly, we previously reported that a 4 mg/kg dose of (+)-Bicuculline is anxiogenic when dams are tested with an elevated plus-maze (Miller et al., 2010), but it was not in the present study.
Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats
2009, Behavioural Brain ResearchUse of the elevated T-maze to study anxiety in mice
2004, Behavioural Brain ResearchThe mouse light/dark box test
2003, European Journal of Pharmacology