Elsevier

Neuropharmacology

Volume 11, Issue 3, May 1972, Pages 427-433
Neuropharmacology

Mechanism of peruvoside-induced emesis

https://doi.org/10.1016/0028-3908(72)90028-7Get rights and content

Abstract

Peruvoside causes emesis in dogs and cats by oral or intravenous routes. There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration of the drug does not cause emesis but a typical “digitalis toxicity syndrome” is seen. The ablation of the chemoreceptor trigger zone fails to eliminate peruvosideinduced emesis, but nodose ganglionectomy eliminates this response. Intracarotid injections of the drug considerably reduce the threshold latency in eliciting emesis. We conclude that peruvoside stimulates receptors in the nodose ganglion to produce emesis.

References (11)

  • H.S. Borison et al.

    Morphology of emetic chemoreceptor trigger zone in cat medulla

  • H.L. Borison et al.

    Mechanism of veratrum-induced emesis in the cat

    J. Pharmac. exp. Ther.

    (1952)
    H.L. Borison et al.

    Mechanism of veratrum-induced emesis in the cat

    J. Pharmac. exp. Ther.

    (1952)
  • M. Dresbach et al.

    K-Strophanthiclin emesis in cats with denervated hearts

    J. Pharmac. exp. Ther.

    (1926)
  • W. Feldberg et al.

    Injections of drugs into the lateral ventricle of the cat

    J. Physiol.

    (1954)
  • B.B. Gainonde et al.

    Central emetic action and toxic effects of digitalis in cats

    J. Pharmac. exp. Ther.

    (1965)
There are more references available in the full text version of this article.

Cited by (5)

  • The physiology and pharmacology of emesis

    1984, Molecular Aspects of Medicine
  • Mechanism of antiemetic action of penfluridol in the dog

    1978, European Journal of Pharmacology
  • Vomiting and antiemetics

    1979, Pharmaceutisch Weekblad Scientific Edition
  • MECHANISM OF NEUROTOXICITY OF CARDIOTONIC GLYCOSIDES

    1977, British Journal of Pharmacology
View full text