Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism
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Cited by (42)
Activation syndrome induced by the antidepressant tianeptine and suicidal ideation: Evidence from a large depressed outpatient sample
2020, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Indeed, contrary to tricyclic antidepressants and SSRIs, tianeptine produces no serotonin recapture (Uzbay, 2008). Tianeptine's antidepressant and anxiolytic effects seem to derive from the modulation of dopamine transmission, a normalization of glutamatergic neurotransmission, and an opioid agonism that produces analgesic activity (Invernizzi et al., 1992). Tianeptine also seems to have memory-protective effect and anti-stress properties on the brain by facilitating neuroplasticity processes (Uzbay, 2008; Zoladz et al., 2008).
Effect of acute and chronic tianeptine on the action of classical antiepileptics in the mouse maximal electroshock model
2013, Pharmacological ReportsCitation Excerpt :Repeated administration of this antidepressant drug increased the functional responsiveness of dopamine D2/D3 receptors [18]. In addition, tianeptine (10 mg/kg, ip) increased extracellular concentration of dopamine in nucleus accumbens and striatum of rat brain [25]. Previous studies have indicated that combined anticonvulsantantidepressant effects may be related to elevated hippocampal dopamine or serotonin concentrations [43].
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT <inf>3</inf> receptors
2012, European Journal of PharmacologyCitation Excerpt :Therefore, our results suggest that α1 and α2-adrenoceptor stimulation may not involved in the antinociceptive effect of tianeptine. On the other hand, tianeptine enhances the extracellular concentration of dopamine in the nucleus accumbens (Invernizzi et al., 1992) and repetitive administration of tianeptine modulates the D2 and D3 dopamine receptors (Dziedzicka-Wasylewska, et al., 2002). Recent studies also show that dopamine receptors also have some role in the antinociception (Li et al., 2012; Ortega-Legaspi et al., 2011).
Reconsidering anhedonia in depression: Lessons from translational neuroscience
2011, Neuroscience and Biobehavioral ReviewsIs it possible to be dependent to Tianeptine, an antidepressant? A case report
2007, Progress in Neuro-Psychopharmacology and Biological PsychiatryTianeptine can be effective in men with depression and erectile dysfunction
2006, Journal of Sexual MedicineCitation Excerpt :Also, tianepitne lacks anticholinergic effects that would potentially impair sexual arousal. Furthermore, although tianeptine is not a dopamine reuptake inhibitor [19], it has been shown to increase dopamine in rat frontal cortex and nucleus accumbens [20,21], a property that might enhance sexual function. Moreover, tianeptine has been reported to have acceptable effects on sexual desire [22] and one of the recommended antidepressants for depressed patients with sexual complications [23].