Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 95, Issues 2–3, August 1982, Pages 363-375
Enumeration of thioguanine-resistant lymphocytes using autoradiography
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Cited by (30)
Strategies and testing methods for identifying mutagenic risks
2000, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCitation Excerpt :The most developed and validated endogenous in vivo system measures mutations at the hprt locus in mammalian lymphocytes. The development of the hprt assay employing human peripheral blood lymphocytes has contributed significantly to our understanding of in vivo somatic cell mutagenesis in the human [92–97]. In vivo chemical/physical mutagenesis assays at the hprt locus in lymphocytes of rodents and non-human primates have also been developed in lymphocytes [98–101], such that the same endpoint can be monitored in laboratory animals or in epidemiology studies involving human subjects.
Bromodeoxyuridine labelling as an alternative method to identify 6- thioguanine-resistant mutant lymphocytes in humans
1999, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisDevelopment and utilization of the rat lymphocyte hprt mutation assay
1997, Mutation Research - Reviews in Mutation ResearchWorking paper no. 3 Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
1994, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisMeasurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations
1993, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisIonizing radiation and genetic risks III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation
1991, Mutation Research/Reviews in Genetic Toxicology
Copyright © 1982 Published by Elsevier B.V.