Elsevier

Life Sciences

Volume 44, Issue 24, 1989, Pages 1871-1875
Life Sciences

Effect of exertion on the stimulation of ornithine decarboxylase activity by growth hormone in rats

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Abstract

To investigate the effect of stressful stimulation on tissue responsiveness to growth hormone (GH), we examined ODC activity as a measure of hepatic sensitivity to the hormone during forced exertion in rats. GH caused a 15-fold increase in ODC activity in the livers of resting rats at 3 hours after the injection of hormone. Forced walking in a rotating cylinder enhanced the effect of GH on ODC activity by up to 66% above the effect in resting rats, and this enhancement was positively related to the speed of rotation of the cylinder. These results suggest that tissue hypersensitivity to GH stimulation is a consequence of forced exertion. This hypersensitivity to GH would tend to compensate for the inhibitory effects of forced exertion on GH secretion in rats.

References (24)

  • J. Janne et al.

    Biochim. Biophys. Acta

    (1968)
  • J. Janne et al.

    Biochim. Biophys. Acta

    (1969)
  • G.J. Kant et al.

    Pharmacol. Biochem. Behav.

    (1983)
  • C.M. Kuhn et al.

    Pharmacol. Biochem. Behav.

    (1983)
  • S. Stefurak et al.

    Pharmacol. Biochem. Behav.

    (1977)
  • M. Bradford

    Anal. Biochem.

    (1976)
  • V.V. Isomaa et al.

    J. Biol. Chem.

    (1983)
  • D.H. Russell et al.

    Endocrinology

    (1969)
  • A.E. Pegg

    Biochim. J.

    (1986)
  • D.H. Russell et al.
  • A.E. Pegg et al.

    Biochem. J.

    (1968)
  • A. Raina et al.

    Med. Biol.

    (1975)

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