Elsevier

Life Sciences

Volume 38, Issue 25, 23 June 1986, Pages 2347-2354
Life Sciences

Cholinergic induction of seizures in the rat prefrontal cortex

https://doi.org/10.1016/0024-3205(86)90642-9Get rights and content

Abstract

Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200–300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.

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