Elsevier

Journal of the Neurological Sciences

Volume 31, Issue 1, January–February 1977, Pages 83-91
Journal of the Neurological Sciences

Increased T3 deiodination in dystrophic and neonatally denervated mouse muscle

https://doi.org/10.1016/0022-510X(77)90007-7Get rights and content

Abstract

T3, free iodide levels and morphological features were compared in normal, 129 ReJ dy/dy dystrophic and neonatally denervated skeletal muscles of mice, killed 6 hr after a single intraperitoneal injection of iodine-labelled hormone.

Both the dystrophic and the denervated muscles were found to contain equal amounts of T3 but more iodide than the normal specimens.

Increased iodide levels are considered to reflect augmented T3-catabolism by muscle dehalogenase and may indicate low free hormone levels in the soluble enzyme fraction of the cell, despite its normal overall T3 content. The close light-microscopic resemblance of 129 ReJ dy/dy dystrophy and neonatal denervation is confirmed. The possibility is discussed that one or several of the muscular dystrophies are forms of target organ hypothyroidism.

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Cited by (2)

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    1986, Bulletin of Experimental Biology and Medicine

This study was supported by the Nederlands Comité voor Kinderpostzegels.

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