Changes in dopamine release in vitro from the corpus striatum of young versus aged rats as a function of infusion modes of l-DOPA, potassium, and amphetamine
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Cited by (27)
The aging striatal dopamine function
2012, Parkinsonism and Related DisordersCitation Excerpt :Early studies showed decreased levels in dopamine tissue content in the rat striatum [53]. In aged rodents [54–58] and aged non-human primates [59], in-vivo monitoring of the extra-cellular content of dopamine (and its first metabolite) by microdialysis confirmed decreased base line levels and evoked response to a high potassium challenge. From this, one can infer that dopamine depletion, but not dopaminergic cell loss, is a hallmark for aging and correlates with the occurrence of motor decline [36] (Fig. 1).
Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo
2008, Brain ResearchCitation Excerpt :Catecholamine dynamics in brain slices are also different from those in the living brain. For instance, K+-evoked DA efflux declines during successive stimulations in vitro (Dluzen et al., 1991) but not in vivo (Ripley et al., 1997; Shui et al., 1998). These considerations prompted us to examine the interaction of tyrosine availability and high-K+ depolarization-induced catecholamine efflux using in vivo microdialysis.
Interactions among ovarian hormones and time of testing on behavioral sensitization and cocaine self-administration
2007, Behavioural Brain ResearchAging and sex differences in striatal dopaminergic function
2007, NeuroscienceCitation Excerpt :There are a number of studies which show no significant age-related differences in K+-stimulated DA release from the striatum (Thompson et al., 1981; Freeman and Gibson, 1987; Joseph et al., 1988; Woodward et al., 1989; Santiago et al., 1993; Kametani et al., 1995; Shui et al., 1998; Gerhardt and Maloney, 1999). A comparable number show significant reductions in potassium-stimulated striatal DA release (Rose et al., 1986; Dluzen et al., 1991, 1988; Stamford, 1989; Laping et al., 1990; Dobrev et al., 1995; Gerhardt et al., 1995; Huang et al., 1995; Nakano and Miziuno, 1996; Hebert and Gerhardt, 1998). A number of potential technical/experimental design differences may exist to explain such disparities.