Electrophysiologic evidence of regeneration of lamprey spinal neurons
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Cited by (14)
RhoA activation in axotomy-induced neuronal death
2018, Experimental NeurologyCitation Excerpt :RhoA inactivation fosters axon growth and functional recovery following SCI (Lehmann et al., 1999; Dergham et al., 2002; Fournier et al., 2003), but because in mammalian SCI experiments it is difficult to distinguish regeneration of severed axons from collateral sprouting by spared axons, it is not clear whether RhoA is suppressing axon regeneration or only sprouting, two processes that appear to have different mechanisms (Lee et al., 2010; Koch et al., 2014). We have used the lamprey as an experimental model to get around this difficulty because its axons regenerate after complete spinal cord injury and regeneration is easily documented by histological and electrophysiological means (Rovainen, 1976; Selzer, 1978; Yin and Selzer, 1983, 1984; Cohen et al., 1988; Davis Jr and McClellan, 1994a; Banerjee et al., 2016). Although lamprey reticulospinal axons can regenerate after SCI, the regeneration is not complete.
Axon Regeneration in the Lamprey Spinal Cord
2015, Neural RegenerationNon-mammalian model systems for studying neuro-immune interactions after spinal cord injury
2014, Experimental NeurologyCitation Excerpt :In most studies of SCI in lamprey, the injury model is a complete transection. Full functional recovery is achieved over a stereotypical time course of 12 weeks, which corresponds to regeneration of reticulospinal axons through the lesion site (Cohen et al., 1986, 1989; Rovainen, 1967, 1976; Selzer, 1978; Wood and Cohen, 1979, 1981; Yin and Selzer, 1984). The lamprey spinal cord is non-myelinated and contains descending axons from reticulospinal neurons, as well as intraspinal motor neurons, sensory neurons and interneurons (Grillner and Jessell, 2009).
Mechanical properties of the lamprey spinal cord: Uniaxial loading and physiological strain
2013, Journal of BiomechanicsCitation Excerpt :A significant amount of force experiments have been done in rodent models, which has allowed us to better understand the biomechanics of the spinal cord (1.2 MPa) and the physiological and in vitro effects of applied forces on nerves (e.g. stretching) (Maikos et al., 2008; Russell et al., 2012; Abe et al., 2002; Bora et al., 1980; Ichimura et al., 2005; Jou et al., 2000; Spiegel et al., 1993; Pfister et al., 2004; Pfister et al., 2006). Our animal model of choice, lamprey (Petromyzon Marinus), is a basal vertebrate model used to study spinal cord regeneration (Cohen et al., 1989; Cohen et al. 1988, 1986; Buchanan and Cohen, 1982; Lurie and Selzer, 1991a, 1991b; Yin and Selzer, 1984, 1983; Oliphint et al., 2010) and animal locomotion (Cohen et al., 1990; Cohen, 1988, 1987; Cohen et al., 1982; Cohen and Wallen, 1980; Tytell et al., 2010). We used the lamprey for its regenerative capabilities after SCI and thus their usefulness in understanding this process.
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We thank Ms. Laurie Youngs for help in preparing figures. Supported by NIH grant NS 14387.