The immediate shift of afferent drive of dorsal column nucleus cells following deafferentation: A comparison of acute and chronic deafferentation in gracile nucleus and spinal cord
References (9)
- et al.
Topography of the projection of the body surface of the cat to cuneate and gracile nuclei
Exp. Neurol.
(1975) - et al.
Restructuring of the somatotopic map and appearance of abnormal neuronal activity in the gracile nucleus after partial deafferentation
Exp. Neurol.
(1976) - et al.
Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation. The appearance of responding cells in a previously non-responsive region
Brain Res.
(1976) - et al.
Cortical suppression of the reticulo-collicular pathway in the monocularly deprived cat
J. Physiol. (Lond.)
(1976)
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2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The changes resulting from attenuation of the afferent input that are manifested both morphologically and functionally in the cortex seem to also occur at all levels within the projection system involved (Merzenich et al., 1984). For instance changes in cortical somatotopic maps in cats also show acute and chronic changes at the level of the spinal cord, dorsal columns and the thalamus following nerve trans-section (Dostrovsky and Millar, 1976; Millar et al., 1976). Similar findings have also been found in monkeys (Merzenich et al., 1981; Merzenich et al., 1983, 1984).
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2012, PainCitation Excerpt :Dorsal root entry zone lesions have been reported to immediately abolish trigger zones associated with nerve root avulsions [25], supporting a primary subcortical mechanism for referral after nerve injury. There is a large amount of literature demonstrating reorganization following deafferentation at the level of the thalamus [5,18] and the gracile and cuneate nuclei of the brainstem [5,9,13,34] in primates and cats. Davis and colleagues [6] found a large representation of the stump in patients with limb amputation, compatible with the expansion of somatotopically adjacent regions into deafferented regions in the thalamus.
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Dr. Dostrovsky is a postdoctoral fellow of the Medical Research Council of Canada.
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The present address of Dr. Millar is the Physiology Department, The London Hospital Medical College, Turner St., London E1.
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This work was supported by the Medical Research Council of Great Britain and by the U. S. National Institutes of Health.