Calcium and magnesium content of rodent photoreceptor cells as inferred from studies of retinal degeneration

doi:10.1016/0014-4835(76)90049-X

Experimental Eye Research

Volume 22, Issue 3, March 1976, Pages 219-228

https://doi.org/10.1016/0014-4835(76)90049-X Get rights and content

Abstract

The content of calcium and magnesium was determined in control and degenerative retinas of mice and rats. The level of both cations was reduced in these disorders during the period of photoreceptor cell degeneration. The number of cells lost from these retina was estimated from DNA measurements, and the divalent cation content of an average photoreceptor cell was computed. From these data and the literature, it is suggested that an average photoreceptor cell of a mouse or rat retina contains 2–3 fmol of calcium, 3–4 fmol of magnesium and about 0·1 fmol of rhodopsin.

References (21)

S.L. Bonting et al.
The rhodopsin cycle in the developing vertebrate retina. I. Relation of rhodopsin content, electroretinograms and rod structure in the rat
Exp. Eye Res.
(1961)
L.L. Caravaggio et al.
The rhodopsin cycle in the developing vertebrate retina. II. Correlative study in normal mice and in mice with hereditary retinal degeneration
Exp. Eye Res.
(1963)
G. Chader et al.
Rod outer segment phosphodiesterase: Factors affecting the hydrolysis of cyclic-AMP and cyclic-GMP
Exp. Eye Res.
(1974)
F.J.M. Daemen
Vertebrate rod outer segment membranes
Biochim. Biophys. Acta
(1973)
J.A. Ferrendelli et al.
Comparison of the effects of biogenic amines on cyclic GMP and cyclic AMP levels in mouse cerebellum in vitro
Brain Res.
(1975)
B. Grafstein et al.
Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors
Brain Res.
(1972)
W.A. Hagins et al.
A role for Ca²⁺ in excitation of retinal rods and cones
Exp. Eye Res.
(1974)
R.N. Lolley et al.
Cyclic nucleotide phosphodiesterases in dystrophic rat retinas: guanosine 3′,5′ cyclic monophosphate anomalies during photoreceptor cell degeneration
Exp. Eye Res.
(1975)
O.H. Lowry et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951)
R.G.G. Andersson
Cyclic AMP and calcium ions in mechanical and metabolic responses of smooth muscle; influence of some hormones and drugs
Acta Physiol. Scand.
(1972)

There are more references available in the full text version of this article.

Cited by (0)

View full text

Article preview

Experimental Eye Research

Abstract

References (21)

The rhodopsin cycle in the developing vertebrate retina. I. Relation of rhodopsin content, electroretinograms and rod structure in the rat

Exp. Eye Res.

The rhodopsin cycle in the developing vertebrate retina. II. Correlative study in normal mice and in mice with hereditary retinal degeneration

Exp. Eye Res.

Rod outer segment phosphodiesterase: Factors affecting the hydrolysis of cyclic-AMP and cyclic-GMP

Exp. Eye Res.

Vertebrate rod outer segment membranes

Biochim. Biophys. Acta

Comparison of the effects of biogenic amines on cyclic GMP and cyclic AMP levels in mouse cerebellum in vitro

Brain Res.

Protein synthesis and axonal transport in retinal ganglion cells of mice lacking visual receptors

Brain Res.

A role for Ca²⁺ in excitation of retinal rods and cones

Exp. Eye Res.

Cyclic nucleotide phosphodiesterases in dystrophic rat retinas: guanosine 3′,5′ cyclic monophosphate anomalies during photoreceptor cell degeneration

Exp. Eye Res.

Protein measurement with the Folin phenol reagent

J. Biol. Chem.

Cyclic AMP and calcium ions in mechanical and metabolic responses of smooth muscle; influence of some hormones and drugs

Acta Physiol. Scand.

Cited by (0)