Muscarinic receptor subtype mediating vasodilation in feline middle cerebral artery exhibits M3 pharmacology
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The pharmacology of McN-A-343
2012, Pharmacology and TherapeuticsCitation Excerpt :Intracerebroventricular injection of McN-A-343 can activate a central cholinergic anti-inflammatory pathway in the vagus nerve that inhibits peripheral production of tumor necrosis factor (TNF) and thus protects from endotoxemia and sepsis (Pavlov et al., 2006). McN-A-343 activated muscarinic receptors in the prepositus hypoglossi nucleus involved in the cholinergic pathway contributing to persistent neural activation necessary for eye-fixation (Delgado-Garcia et al., 2006). Central administration of McN-A-343 into the rat lateral hypothalamic nucleus stimulated pancreatic enzyme secretion (Li et al., 2003) (see Section 4.3: Pancreas).
Receptor-Mediated Events in the Microcirculation
2008, MicrocirculationVasodilatory effects of cholinergic agonists are greatly diminished in aorta from M<inf>3</inf>R<sup>-/-</sup> mice
2004, European Journal of Pharmacology
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