Auditory and colored visual P300 in patients with sequelae of subacute myelo-optico-neuropathy

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Abstract

To study the cognitive function in 13 patients with sequelae of subacute myelo-optico-neuropathy (SMON), event-related potentials (ERPs) were elicited with tones, clicks, and colored visual stimuli in different tasks. P300 latency was delayed, and P300 amplitude reduced or absent in 5 patients (38%), although neuropsychological assessment for dementia did not differ between patients and 21 age-matched normal controls. P300 and N200 latencies with the tone/tone auditory stimuli and N200 latency with the visual stimuli were significantly delayed, but the latencies of early components (N100 and P200) were not delayed. These findings suggest that SMON patients may have cognitive dysfunction to a slight degree.

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    1

    We thank Prof. Makoto Futatsuka, M.D., Department of Public Health, Kumamoto University School of Medicine, for his useful advice, and Makoto Shindo and Naoyuki Yoshitake, sales engineers, Mansson Co. Inc., for designing a computer program to produce visual stimulation in the ERP study. We are also grateful to John Polich, Ph.D., Department of Neuropharmacology, The Scripps Research Institute, USA, for his valuable comments and advice.

    ∗∗

    Present address: Kumamoto Health Care Center, Japan Red Cross Society, 2255-209 Nagamine-machi, Kumamoto 862, Japan.

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