Erythrocyte cation transport activities as a function of cell age

doi:10.1016/0009-8981(86)90315-3

Clinica Chimica Acta

Volume 157, Issue 1, 30 May 1986, Pages 33-43

https://doi.org/10.1016/0009-8981(86)90315-3 Get rights and content

Abstract

Erythrocyte cation transport systems were evaluated on cell fractions from 17 subjects. Density centrifugation was used to separate washed red cells into fractions enriched with younger and older cells; the cell age differences in these fractions were verified by reticulocyte counts (means are 3.5% for younger cell fractions and 0.7% for older cell fractions). Red cell age has a pronounced effect on several cation transport activities. The older cell fractions had increases in lithium-potassium cotransport (p < 0.001), the rate constant for the lithium-potassium cotransport (p < 0.001) and cellular cation permeability. The older cells had decreases in the number of ouabain binding sites (p < 0.001), the rate constant for sodium efflux via the sodium-potassium adenosine triphosphatase pumps (p < 0.001) and the sodium-lithium countertransport (p < 0.025). In subjects with markedly different cell ages, these effects should be considered when evaluating red cell cation transport activities.

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Erythrocyte cation transport activities as a function of cell age

Abstract

Lancet

Clin Chim Acta

Clin Chim Acta

Clin Chim Acta

Biochim Biophys Acta

Am J Obstet Gynecol

Blood

Clin Chim Acta

Increased sodium-lithium countertransport in red cells of patients with essential hypertension

N Engl J Med

Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents

N Engl J Med

Inherited defect in a Na+,K+-cotransport in erythrocytes from essential hypertensive patients

Nature (London)

Abnormal erythrocyte Na+,K+-cotransport system, a proposed genetic marker of essential hypertension

Clin Exp Hypertens

The relationship of lithium-potassium cotransport and the passive lithium leak to hypertension in Utah subjects

Clin Exp Hyperten: Theory and Practice

Three red cell sodium transport systems in hypertensive and normotensive Utah adults

Hypertension

Inherited defect in a Na⁺,K⁺-cotransport in erythrocytes from essential hypertensive patients

Abnormal erythrocyte Na⁺,K⁺-cotransport system, a proposed genetic marker of essential hypertension