Synthesis and stability of [3H] 5—demethoxyubiquinone-9
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Altered Quinone Biosynthesis in the Long-lived clk-1 Mutants of Caenorhabditis elegans
2001, Journal of Biological ChemistryCitation Excerpt :The mutant mitochondria instead exhibited a major peak eluting 1 min earlier than UQ9 (Fig. 1, C–E). The slightly polar nature and the absorption property (absorption peak at 270 nm, Fig. 2 B) of this compound coincide well with those reported for the ubiquinone biosynthesis intermediate, DMQ9(see Fig. 3) (19, 23). A mass spectrometry analysis of the accumulated quinone in clk-1(qm51) mutant detected a molecular ion peak atm/z 765, which corresponds to the molecular mass of DMQ9 (theoretical mass [C53H80O3] = 765.2005) (Fig.4).
The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis
1996, Journal of Biological ChemistryBiosynthesis of Ubiquinone
1983, Vitamins and HormonesNew concepts on the role of ubiquinone in the mitochondrial respiratory chain
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Part of this report was taken from a dissertation submitted by Bernard L. Trumpower to St. Louis University (1969) in partial fulfillment of the requirement for the Ph.D. degree. Present address: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA.
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Present address: Department of Chemistry, Presbyterian College, Clinton, South Carolina, USA.