Comparative analysis of splenic cell proliferation induced by interleukin 3 and by syngeneic accessory cells (syngeneic mixed leukocyte reaction): Evidence that autoreactive T-cell functioning instructs hematopoietic phenomena
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G-CSF-treated granulocytes inhibit acute graft-versus-host disease
2006, BloodCitation Excerpt :One day before transplantation, (C57BL/6 × BALB/c) F1 recipients received 850 cGy total body irradiation (TH780C irradiator with a cobalt Co 60 [60Co] source). For all experiments, 5 × 106 BMTD cells plus 5 × 106 nonadherent nylon wool spleen (NWS)29 cells from C57BL/6 donors were injected intravenously into (C57BL/6 × BALB/c) F1 recipients. NWS cells were from normal donors (NWS) or donors treated for 5 days with rhG-CSF (G-NWS), depleted or not depleted of granulocytes with anti-Gr1 mAb and complement.
Normal hematopoiesis is maintained by activated bone marrow CD4<sup>+</sup> T cells
2005, BloodCitation Excerpt :In addition, BM engraftment after bone marrow transplantation (BMT) has been shown to depend on T cells, since T-cell–depleted allogeneic BMT (for graft versus host disease [GVHD] prophylaxis) increases the risk of graft failure in about 70% in clinical and experimental approaches.19,20 Complete posttransplantation recovery and HSC maintenance in different animal models suggest a major histocompatibility complex (MHC) class II dependency21,22 and imply a role for CD4+ T cells in hematopoietic recovery. It is yet to be established if the effects of T cells in hematopoiesis are consequent to T-cell activity in the bone marrow or in the periphery.
A T cell view of the bone marrow
2016, Frontiers in Immunology
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Present address: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.