Glucose attenuation of atropine-induced deficits in paradoxical sleep and memory

doi:10.1016/0006-8993(95)00810-D

Brain Research

Volume 694, Issues 1–2, 2 October 1995, Pages 133-138

https://doi.org/10.1016/0006-8993(95)00810-D Get rights and content

Abstract

When administered systemically, glucose attenuates deficits in memory produced by several classes of drugs, including cholinergic antagonists and opiate agonists. Glucose also enhances memory in aged rats, mice, and humans. In addition, glucose ameliorates age-related reductions in paradoxical sleep. Because deficits in paradoxical sleep are most marked in those individual aged rats that also have deficits in memory, treatments which improve one of these functions may similarly improve the other. The present experiments show that glucose attenuates deficits in paradoxical sleep and memory after atropine administration, with similar dose-response curves for both actions. In the first experiment, rats received saline, atropine (1 mg/kg), glucose (100 mg/kg) or combinations of atropine + glucose (10, 100, 250, and 500 mg/kg) 30 min before assessment on a spontaneous alternation task. In the second experiment, 3-h EEGs were assessed for spontaneous daytime sleep in rats administered saline, atropine (1 mg/kg), glucose (100 mg/kg) or combinations of atropine + glucose (10, 100 and 250 mg/kg). In both experiments, glucose significantly attenuated deficits at an optimal dose of 100 mg/kg. A third experiment assessed blood glucose levels after injections of atropine + glucose (100 mg/kg) and determined that blood glucose levels were similar to those produced by other treatments which enhance memory. These results are consistent with the view that paradoxical sleep and at least one test of memory are similarly influenced by atropine and glucose.

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¹: Present address: The Brockton/West Roxbury VAMC, Psychology Service (116B), 940 Belmont St., Brockton, MA 02401, USA.

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Research reportGlucose attenuation of atropine-induced deficits in paradoxical sleep and memory

Abstract

Physiol. Behav.

Brain Res.

Eur. J. Pharmacol.

Neurobiol. Aging

Behav. Brain Res.

Pharmacol. Biochem. Behav.

Behav. Neural Biol.

Brain Res.

Brain Res.

Neurosci. Biobehav. Rev.

Neurobiol. Aging

Brain Res.

Behav. Neural Biol.

Brain Res.

Morphine-induced deficits in sleep patterns: Attenuation by glucose

Neurobiol. Learning Memory

Research report
Glucose attenuation of atropine-induced deficits in paradoxical sleep and memory