Reductions in body weight following chronic central opioid receptor subtype antagonists during development of dietary obesity in rats
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Western diet consumption does not impact the rewarding and aversive effects of morphine in male Sprague-Dawley rats
2023, Physiology and BehaviorDynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction
2017, International Review of NeurobiologyCitation Excerpt :In the same study, activation of KORs in food-sated rats increased consumption of high-fat food with no effect on consumption of low-fat food (Ookuma, Barton, York, & Bray, 1997). Another study showed that KOR inhibition blocked short-term consumption of palatable high-fat diet (Arjune & Bodnar, 1990), and chronic KOR inhibition prolonged the effects of reduction in the consumption of fat but not total intake in rats exposed to a diet of fat, low-fat pellets, milk, and water (Cole, Leventhal, Pasternak, Bowen, & Bodnar, 1995). In addition, KOR inhibition selectively reduced deprivation-induced high-fat food consumption in rats that were genetically susceptible to obesity (Osborne–Mendel rats) while having no effect on effect on low-fat diet intake in these animals.
Neural responses to macronutrients: Hedonic and homeostatic mechanisms
2015, GastroenterologyCitation Excerpt :Suppression of OPRM1 in the NAc not only reduces food reward behavior,126 but also reduces diet-induced obesity.127 These findings support the role of opioid circuits in rodent models of obesity and hyperphagia.128,129 As discussed to several reviews of neuroimaging studies of obesity,108,130 one clinical study found that during weight gain, subjects had reduced striatal responses to palatable foods, compared with subjects with stable weight.131
Critical role of NMDA but not opioid receptors in the acquisition of fat-conditioned flavor preferences in rats
2012, Neurobiology of Learning and MemoryCitation Excerpt :To this end, different doses of NTX or MK-801 were injected systemically either prior to testing (expression experiments) or training (acquisition experiments) sessions. Based on the observed reductions in fat intake produced by NTX (Cole et al., 1995; Dym et al., 2010; Glass, Billington, & Levine, 2000; Higgs & Cooper, 1998; Islam & Bodnar, 1990; Jarosz et al., 2006; Marks-Kaufman et al., 1985; Naleid et al., 2007; Sahr et al., 2008; Zhang et al., 1998), we expected that opioid receptor antagonism would impair both the acquisition and expression of CO-CFP. Based upon the ability of MK-801 to block the acquisition, but not the expression of fructose-CFP (Golden & Houpt, 2007) and its other effects on food learning (Hernandez et al., 2005; Kelley et al., 1997; Stuber et al., 2008; Yasoshima et al., 2000; Zellner et al., 2009; Zweifel et al., 2009), we expected that NMDA receptor antagonism would impair the acquisition, but not the expression of CO-CFP.