Research reportReduced retinal activity increases GFAP immunoreactivity in rat lateral geniculate nucleus
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Cited by (24)
Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension
2009, Brain ResearchCitation Excerpt :Within 6 h of enucleation, GFAP-IR was increased in the contralateral LGN. A similar increase in GFAP-IR can be induced by intraocular injections of tetrodotoxin (TTX), demonstrating that reversible manipulation of optic nerve electrical activity is sufficient to regulate LGN astrocytes (Canady et al., 1994). It is known that presynaptic and postsynaptic compartments, together with the enveloping astrocyte processes, form the tripartite synapse (Agulhon et al., 2008).
Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model
2008, Experimental Eye ResearchCitation Excerpt :Although there are many reports of GFAP expression in the retina, its expression in LGN is not fully understood. Reportedly, GFAP expression in LGN is upregulated when either the neuronal input from the retina (Canady et al., 1994; Gonzalez et al., 2006) or feedback transduction from the visual cortex (Agarwala and Kalil, 1998) is completely abolished. In the present study, we found that high IOP induced a partial visual field loss (about a 9 dB reduction in mean threshold versus baseline) and also increased GFAP expression in those LGN layers that receive a neuronal input from the high IOP eye (versus those receiving from the contralateral untreated one).
Visual System
2004, The Rat Nervous SystemGlial reaction and reactive glia
2003, Advances in Molecular and Cell BiologyCitation Excerpt :In general, the enhanced expression of GFAP seems to be the main indicator of the activation of astroglia (Eddleston and Mucke, 1993; Norenberg, 1994). However, an increase of GFAP-expression does not always indicate reactive gliosis, but occurs also as a consequence of different neural activities (Kraig et al., 1991; Steward et al., 1991, 1997; Canady et al., 1994) or hormonal effects (see e.g., Garcia-Segura et al., 1999; Hajós et al., 2000 as well as Section 9.7). As GFAP-expression during evolution seemed to decrease to the lowest possible level (Kálmán, 2002), it is not surprising that microenvironmental alterations are usually followed by upregulation of GFAP, whereas downregulation is infrequent (for an example, see Missler et al., 1994).