Research reportAnimals predisposed to develop amphetamine self-administration show higher susceptibility to develop contextual conditioning of both amphetamine-induced hyperlocomotion and sensitization
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Reversal of apomorphine locomotor sensitization by a single post-conditioning trial treatment with a low autoreceptor dose of apomorphine: A memory re-consolidation approach
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :This behavioral sensitization drug effect has been repeatedly demonstrated (Borowski and Kuhn, 1991; Heidbreder and Shippenberg, 1994; Mattingly et al., 1994; Carey and Gui, 1998; Bloise et al., 2007; Braga et al., 2009a,b; Dias et al., 2010; Filip et al., 2010; Matos et al., 2010) and is generally considered an important contributor to the addictive potency of psychostimulant drugs such as cocaine (e.g., Robinson and Berridge, 1993; Carey and Damianopoulos, 2006). Thus, it would appear that psychostimulant behavioral sensitization effects are a composite of the conditioned effects plus an increased unconditioned drug response (Peris et al., 1990; Pert et al., 1990; Henry and White, 1991; Zeigler et al., 1991; Kalivas et al., 1992; Robinson and Berridge, 1993; Jodogne et al., 1994; Carey et al., 2005a; Braga et al., 2009a,b; Dias et al., 2010). The quantitative contribution of Pavlovian conditioned drug effects to behavioral sensitization, nonetheless, remains rather obscure (Einat et al., 1996).
The contribution of the central nucleus of the amygdala to individual differences in amphetamine-induced hyperactivity
2009, Behavioural Brain ResearchEffects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
2008, Neurobiology of DiseaseCitation Excerpt :For example, in rodents some subjects, remarkably active upon the first exposure to an open field (High Responders, HR), present an increased vulnerability to drugs whereas rats that have a somewhat reduced reactivity to novel environments (Low Responders, LR) are relatively resistant (Piazza et al., 1989, 2000). This vulnerability is characterized by an augmented sensitivity to the conditioned (Jodogne et al., 1994) and unconditioned (Piazza et al., 1989) effects of drugs and by an increase in self-administration of drugs (Piazza et al., 2000). In addition, recent work in rodents shows that a behavior that presents striking similarities to the behavioral profile of addicts develops after a long period of cocaine self-administration.
The relationship between the locomotor response to a novel environment and behavioral disinhibition in rats
2008, Drug and Alcohol DependenceBupropion hydrochloride produces conditioned hyperactivity in rats
2007, Physiology and BehaviorCitation Excerpt :However, the dissociation between reactivity to inescapable novelty and bupropion unconditioned and conditioned activity might distinguish bupropion from classic stimulants with abuse potential. Reactivity to inescapable novelty has been shown to predict locomotor response to amphetamine, cocaine, and methamphetamine [15,20,21,24,41,42]. The reactivity to inescapable novelty represents differential stress responses and produces elevated corticosterone [20,21,43].