Elsevier

Brain Research

Volume 613, Issue 2, 11 June 1993, Pages 291-294
Brain Research

Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

https://doi.org/10.1016/0006-8993(93)90913-8Get rights and content

Abstract

Although coadministration ofN-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7–10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.

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This work was supported by US Public Service Grant DA-07735 (M.W.), the National Alliance for Research on Schizophrenia and Depression (M.W.), the Pharmaceutical Manufacturers Association Foundation (M.W.), and a National Research Service Award (DA 05434) to M.J.

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Present address: M. Jeziorski, The Whitney Laboratory, 9505 Ocean Shore Blvd., St Augustine, FL 32086-9604, USA.

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