Elsevier

Brain Research

Volume 604, Issues 1–2, 26 February 1993, Pages 338-341
Brain Research

Cholecystokinin receptor density in the striatum of the spontaneously hypertensive rat

https://doi.org/10.1016/0006-8993(93)90387-3Get rights and content

Abstract

The possibility that cholecystokinin in the striatum may be involved in hypertension was investigated using in vitro receptor autoradiography. The binding density of125I-Bolton Hunter labeled cholecystokinin octapeptide (125I-BH-CCK8) was determined using computer-assisted densitometry in the striatum of the spontaneously hypertensive rat (SHR) and its control the Wistar-Kyoto rat (WKY). A significant increase in125I-BH-CCK8 binding density was found in the lateral part of the caudate-putamen of the SHR. In contrast, a significant decrease in125I-BH-CCK8 binding density was found in the posteromedial nucleus accumbens of the SHR. These results indicate that CCK8 receptor density is altered in the striatum of the SHR and suggest a role for CCK8 receptors in the pathophysiology of hypertension.

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    • Cited by (0)

    This work was funded by the Medical Research Council of Canada. G.J.K. is a recipient of a University of Manitoba Graduate Fellowship and P.K.G. is a Scholar of the Heart and Stroke Foundation of Canada.

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