Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy
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Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice
2022, Neuroscience LettersCitation Excerpt :Since spontaneous pain is more common and distressing than evoked pain in patients with NeP, in addition to evoked pain such as hyperalgesia and allodynia to heat, cold or mechanical stimulation, spontaneous pain-related behavior should be evaluated in NeP animal models as preclinical studies [20]. In previous studies, weight bearing disturbances such as GPS and paw licking and flinching were observed for several weeks in animals with various types of NeP [11,21,22], suggesting that GPS and flinching examined in this study would at least in part reflect spontaneous pain seen in patients with NeP. However, this study did not show the involvement of αCGRP in spontaneous pain as well as its involvement in mechanical and thermal hyperalgesia.
Glycosphingolipid Biosynthesis Pathway in the Spinal Cord and Dorsal Root Ganglia During Inflammatory Pain: Early and Late Changes in Expression Patterns of Glycosyltransferase Genes
2020, NeuroscienceCitation Excerpt :For example, knocking out the glycosyltransferase gene St8sia1 in mice results in thermal hyperalgesia, mechanical allodynia, and reduced nociceptive behavior during the late phase of the pain-inducing formalin test (Handa et al., 2005). Intrathecal or intraperitoneal injection of ganglioside GM1a provides effective analgesia in a rat model of neuropathic pain (Hayes et al., 1992; Mao et al., 1992a,c), and reverses abnormal nociception in aged rats (Goettl et al., 2000). Findings in our previous study are consistent with these reports, showing that intraplantar injection of ganglioside GT1b induces nociceptive behavior, specifically, hyperalgesia after a low-dose (0.05%) formalin injection into the hind paws of mice and mechanical allodynia (Watanabe et al., 2011; Watanabe et al., 2017).
Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism
2011, PainCitation Excerpt :Handa et al. reported that St8sia1 knockout mice display both thermal and mechanical allodynia and reduced nociceptive behavior during the late phase of the formalin test [9]. However, GM1 accumulation in these knockout mice makes it difficult to determine the nociceptive roles b-series gangliosides play because in rats, intrathecal or intraperitoneal GM1 injections provide effective analgesia against neuropathic pain [10,17,18] and in aged rats, reverses abnormal nociception [8]. Thus, accumulated GM1 in St8sia1 knockout mice may affect the nociceptive behavior.
Chapter 12 Investigation of brainstem: descending pain modulation in animals and humans
2006, Supplements to Clinical NeurophysiologyD-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cγ up-regulation
2003, Brain ResearchCitation Excerpt :Several lines of evidence indicates that activation of spinal PKC enhances neuronal excitability, and this may contribute to hyperalgesia [31,32]. Furthermore, inhibitors of PKC translocation or activation attenuate nerve injury-induced thermal hyperalgesia [23,50]. An increase in the PKCγ isoform in the superficial dorsal horn of the rat spinal cord is also seen in peripheral nerve injury-induced neuropathic pain syndromes in rats [25,27].