Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever

doi:10.1016/0006-8993(89)91267-5

Brain Research

Volume 476, Issue 2, 9 January 1989, Pages 396-399

https://doi.org/10.1016/0006-8993(89)91267-5 Get rights and content

Abstract

Lesions of the preoptic area of rabbits caused hyperthermia, although they did not alter sleep-coupled changes in brain temperature, and reduced slow-wave sleep, rapid eye movement sleep, and amplitudes of electroencephalographic slow waves during slow wave sleep. The direction and magnitude of the muramyl dipeptide-induced responses were similar before and after the lesions, although the baseline values upon which the changes were superimposed had shifted.

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^☆: This work was supported in part by the National Institutes of Health (NS-25378 and NS-22716), the Office of Naval Research (N00014-85-K-0773), and the U.S. Army Medical Research and Development Command (DAMD-17-86-C-6194).

^∗: Present address: Jerusalem Mental Health Center, Ezrath Nashim, Givat Shaul, P.O. Box 140, Jerusalem, Israel.

¹: We thank Dr. Ferenc Obal, Jr. for his help in the preparation of this manuscript.

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Short communicationEffects of preoptic area lesions on muramyl dipeptide-induced sleep and fever☆

Abstract

Acute and chronic effects of preoptic lesions

Acta Physiol. Scand.

Thermal and chemical stimulation of the hypothalamic heat detectors: the effects on the EEG

Acta Physiol. Sci. Hung.

Hypothalamic sensitivity to leukocyte pyrogen of adult and newborn guinea-pigs

J. Physiol. (Lond.)

Production of prostaglandin E and interleukin-1 like factor by cultured astrocytes and C6 glioma cells

J. Immunol.

Short communication
Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever☆

Production of prostaglandin E and interleukin-1 like factor by cultured astrocytes and C₆ glioma cells