Heterogenous responses of neostriatal neurons to amphetamine in freely moving rats
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Cited by (42)
Amphetamine's dose-dependent effects on dorsolateral striatum sensorimotor neuron firing
2013, Behavioural Brain ResearchBilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats
2007, Neurobiology of AgingCitation Excerpt :These increases are similar to what has been reported in 6-hydroxydopamine-depleted rats [11,27], and are thought to result from disrupted dopaminergic modulation of corticostriatal glutamate projections [6]. Results from a number of labs have demonstrated that individual striatal neurons can be characterized according to their relationship to motor activity [15,35,38,43,44]. In an attempt to study functionally characterized striatal neurons in aged rats, we recently examined electrophysiological activity in locomotor-related striatal neurons in young versus aged Fischer 344 (F344) rats.
Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: Differential involvement of dopamine D<inf>1</inf> and D<inf>2</inf> receptors
2003, Brain ResearchCitation Excerpt :Analysis of concurrent neuronal activity and behavior in the VEH/MDMA group revealed that 63% of recorded units increased activity during spontaneous locomotion when compared to firing rates during quiet resting behavior. This is consistent with previous studies in freely moving rats, which reported excitatory movement-related activity in the majority of striatal cells [14,23,24,56,58,68,69]. Further analysis revealed that MDMA excited 71% of movement-related units, but only 46% of units associated with non-movement-related activity or movement-related inhibitions.
Aged F344 rats exhibit an increased proportion of dopamine agonist-excited striatal neurons
2002, Neurobiology of AgingCitation Excerpt :While previous studies have demonstrated age-related changes in striatal electrophysiology in anesthetized animals and in vitro [2,4,12,24,42,44], there is a paucity of data regarding striatal activity in young versus aged freely-moving rats [40]. Additional studies using freely-moving animals are warranted based on reported differences in striatal electrophysiological activity between anesthetized versus behaving animals (e.g. [9,21,36]). Previous single-unit recording studies utilizing freely-moving rats have demonstrated that systemic and local administration of d-amphetamine (D-AMPH) increases the firing rate of motor-related striatal neurons, but inhibits the firing rate of neurons that are not related to motor activity [9,14,15,47].
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Present address: Center for the Health Sciences, University of Tennessee, 875 Monroe Avenue, Memphis, TN 38163, U.S.A.