Elsevier

Brain Research

Volume 421, Issues 1–2, 22 September 1987, Pages 377-381
Brain Research

Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

https://doi.org/10.1016/0006-8993(87)91312-6Get rights and content

Abstract

Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV–VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.

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    This work was supported in part by funds from the Department Psychiatry and from Pfizer, Groton, CT.

    1

    We thank Adela Sussman for typing the manuscript. Sertraline was a gift from Pfizer.

    *

    Present address: Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, U.S.A.

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