Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: Histochemical and neurochemical analysis
Reference (34)
- et al.
Effects of phosphorylating conditions on tyrosine hydroxylase activity are influenced by assay conditions and brain region
Life Sci.
(1981) - et al.
On the use of the fluorescence histochemical method to estimate catecholamine content in brain
Neuropharmacology
(1975) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Biochem.
(1976)- et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Simultaneous determination of catecholamines and unconjugated 3,4-dihydroxyphenylacetic acid (DOPAC) by ion-pairing reverse-phase high performance liquid chromatography with electrochemical detection
Anal. Biochem.
(1980) - et al.
Short-term effects of dopamine-depleting brain lesions on spontaneous activity of striatal neurons: relation to local dopamine concentration and behavior
Brain Research
(1986) - et al.
Photometric assessment of glyoxylic acid-induced fluorescence of dopamine in the caudate nucleus
Neuroscience
(1982) - et al.
Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. 1. Microestimation of [3H]dopamine uptake and dopamine content in microdiscs
Brain Research
(1976) - et al.
Hyperactivity of remaining dopaminergic neurons after partial destruction of the nigro-striatal dopaminergic system in the rat
Nature (London)
(1973) - et al.
A study of the factors affecting the aluminum oxide-trihydroxyindole for the analysis of catecholamines
J. Pharmacol. Exp. Ther.
(1962)
Importance of fixation in immunohistochemistry: use of formaldehyde solutions at variable pH for the localization of tyrosine hydroxylase
J. Histochem. Cytochem.
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine
Br. J. Pharmacol.
A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: the SPG method
Histochemistry
Quantitative microfluorimetry of formaldehyde induced fluorescence of dopamine in the caudate nucleus
Med. Biol.
Fluorescence of catecholamines and related compounds condensed with formaldehyde
J. Histochem. Cytochem.
Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine cell projections to the basal forebrain and neostriatum
J. Comp. Neurol.
Partial damage to the noradrenergic bundle increases tyrosine hydroxylase activity in noradrenergic terminals of hippocampus but not cerebellum
Brain Research
Cited by (123)
Characterisation of functional deficits induced by AAV overexpression of alpha-synuclein in rats
2023, Current Research in NeurobiologyNeuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease
2017, Experimental NeurologyFrom Man to Mouse: The MPTP Model of Parkinson Disease
2015, Movement Disorders: Genetics and Models: Second EditionImmunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine
2013, Experimental and Toxicologic PathologyCitation Excerpt :The possibility of spontaneous recovery in the striatal dopaminergic system in MPTP-treated C57BL/6 young mice has been explained as a consequence of a regenerative sprouting from remaining intact fibers (Mitsumoto et al., 1998). In the rat 6-OHDA model, it has been shown that the intranigral administration led to a sprouting of dopaminergic fibers in the ipsilateral striatum, although this partial recovery occurred from the fourth month and continued to the seventh month post lesion, but it was not recorded at 10 days post treatment (Blanchard et al., 1996; Onn et al., 1986). Moreover, on the basis of some previous reports (Jackson-Lewis et al., 1995; Jakowec et al., 2004), we think that another possible explanation for the trend for slightly higher immunoreactivity observed at days 15 and 21 post injection could be the upregulation of TH biosynthesis from the non-degenerative neurons in the nigrostriatal axis.
Compensatory Mechanisms in Experimental and Human Parkinsonism: Potential for New Therapies
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :These include the following: (i) increased SNc neuronal activity leading to increase DA release and turnover (Zigmond et al., 1990); (ii) reduced DA transporter (DAT) expression to augment DA synaptic availability; (iii) increased DA receptor sensitivity. The preferential implication of the nigrostriatal DA pathway in the compensatory preservation of DA function has been supported by studies showing an increase in DA release, DA turnover, DA uptake and tyrosine hydroxylase activity/protein after nigrostriatal damage in animal models and in the brain of patients with PD (Bernheimer et al., 1973; Onn et al., 1986; Snyder et al., 1990; Zigmond et al., 1990; Hornykiewicz, 1998; Pifl and Hornykiewicz, 2006; Perez et al., 2008) (Fig. 37.1). Indeed, it was the seminal work of Hornykiewicz in the brain of a few PD patients where it was first shown that the ratio of DA to its striatal metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) was increased in patients with mild symptoms (Bernheimer et al., 1973; Zigmond et al., 1990).
Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
2009, Neuroscience and Biobehavioral Reviews