Elsevier

Brain Research

Volume 371, Issue 1, 16 April 1986, Pages 182-186
Brain Research

Ionic channels in the node of Ranvier are not modulated by cyclic adenosine monophosphate

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Abstract

The effect of a cyclic adenosine monophosphate (cAMP) analogue on myelinated axons was studied. The lipophilic dibutryl cAMP (dbcAMP) was applied to isolated frog axons under voltage clamp conditions. No effect on the ionic currents was observed for either external or internal application of dbcAMP. Nor was any effect of the phosphodiesterase inhibitor teophylline found. These results suggest that cAMP does not play an essential role for nerve impulse conduction in axons. This conduction deviates from those of other studies.

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    This investigation was supported by the Swedish Medical Research Council (Project 6552) and Karolinska Institutes Fonder.

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