β-Adrenoceptor subtypes in the human brain: autoradiographic localization

doi:10.1016/0006-8993(85)90977-1

Brain Research

Volume 358, Issues 1–2, 9 December 1985, Pages 324-328

https://doi.org/10.1016/0006-8993(85)90977-1 Get rights and content

Abstract

The distribution and characteristics of β-adrenoceptors in postmortem human brain was studied using quantitative autoradiographic techniques.¹²⁵I-Cyanopindolol was used as a ligand. High densities of β-adrenoceptors were found in the caudate, putamen, different cortical areas and layers and the hippocampal formation. Low densities were present in other areas such as the thalamus, hypothalamus, midbrain and cerebellar cortex. Specific β₁andβ₂ antagonists were used to visualize and quantify separately the two subtypes of β-adrenoceptors. Computer analysis of the competition curves obtained revealed that the putamen was enriched in β₁ sites while the cerebellum contained predominantly β₂ adrenoceptors. The regional distribution of β-adrenoceptor subtypes was found to be similar to that seen in the rat brain.

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^†: The authors would like to thank Dr. R. Foote for critical reading of the manuscript.

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β-Adrenoceptor subtypes in the human brain: autoradiographic localization

Abstract

Lancet

Eur. J. Pharmacol.

Brain Research

Neuroscience

Neuropharmacology

J. Biol. Chem.

Brain Research

Trends Neurosci.

Neurochem. Int.

Brain Research

Brain Research

Life Sci.