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2017, Journal of Pharmacological SciencesCitation Excerpt :Hippocampal slices can be used for in vitro epilepsy models and pharmacological validation (7). Epileptiform hyperactivity is induced by proconvulsants (8), electrical stimulation (9), and extracellular ionic changes (10). In these cases, seizure-like events (SLE), as sustained synchronous neuronal discharges, are considered hallmarks (2) and are detectable in local field potentials (LFPs).
Complex metabolically demanding sensory processing in the olfactory system: Implications for epilepsy
2014, Epilepsy and BehaviorCitation Excerpt :CA3 bursting resembles the abnormal synchronous interictal activity that is a hallmark of TLE in humans [34]. The hippocampal CA3 region has naturally occurring recurrent excitatory connections, which can produce “bursting” if GABAA inhibition is removed, extracellular potassium is increased, or high-frequency stimulation is applied [35–41]. The kainate- or pilocarpine-treated rat serves as an animal model for TLE.
Diphenytoin, riluzole and lidocaine: Three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity
2013, NeuropharmacologyCitation Excerpt :Lastly, we examined the role of LIDO, which blocks sodium channels and is used clinically to treat seizures. It is also used as a local anesthetic and anti-arrhythmic agent, and has been recently examined for its role in treating neonatal and childhood SE (Stoelting and Hillier, 2006; Hattori et al., 2008; Yamamoto et al., 2007). When 100 μM LIDO was bath applied to CA3 bursts, interburst intervals significantly increased compared to baseline while burst length significantly decreased (Fig. 4).