Electrophysiological studies on benzodiazepine antagonists
References (39)
- et al.
Modification of the anticonvulsant efficacy of diazepam by Ro 15-1788 in the kindled amygdaloid seizure model
Life Sci.
(1982) - et al.
Spontaneous inhibitory post-synaptic potentials in hippocampus: mechanism for tonic inhibition
Brain Research
(1980) - et al.
Proconvulsant effects in baboons of β-carboline, a putative endogenous ligand for benzodiazepine receptors
Neurosci. Lett.
(1981) - et al.
Modulation of benzodiazepine receptor binding: insight into pharmacological efficacy
Europ. J. Pharmacol.
(1982) - et al.
The anxiogenic action of benzodiazepine antagonists
Neuropharmacology
(1982) Water soluble benzodiazepines with agonistic and antagonistic actions on GABA-induced inhibition in cultured hypothalamus
Neurosci. Lett.
(1979)Histamine actions on activity of cultured hypothalamic neurons: evidence for mediation by H1-and H2- histamine receptors
Develop. Brain Res.
(1981)- et al.
Synaptic organization of tuberal hypothalamus in tissue culture: effects of electrical stimulation and blockers of synaptic transmission
Exp. Neurol.
(1979) - et al.
A simple perfusion chamber for the study of nervous tissue slices in vitro
J. Neurosci. Meth.
(1979) - et al.
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors
Europ. J. Pharmacol.
(1981)
Properties of3H-β-carboline-3-carboxyl ethyl ester binding to the benzodiazepine receptor
Life Sci.
Antagonism of benzodiazepine receptors by beta carbolines
Life Sci.
Ethyl-β-carboline-3-carboxylate antagonizes the action of GABA and benzodiazepines in the hippocampus
Brain Research
3-hydroxymethyl-β-carboline antagonizes some pharmacological actions of diazepam
Europ. J. Pharmacol.
GABA reduces binding of3H-methyl β-carboline-3-carboxylate to brain benzodiazepine receptors
Nature (Lond.)
Interaction of convulsive ligands with benzodiazepine receptors
Science
Enhancement of synaptic transmission by 4-aminopyridine in hippocampal slices of the rat
J. Physiol. (Lond.)
β-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors
J. Med. Chem.
Action of betacarboline in flunitrazepam-photolinked cultures
Soc. Neurosci. Abstr.
Cited by (26)
Endozepines and their receptors: Structure, functions and pathophysiological significance
2020, Pharmacology and TherapeuticsCitation Excerpt :Similarly, most experiments testing the effect of flumazenil rather suggest that the net effect of endogenous GABAAR modulators acting at the BZ-binding sites is PAM contribution. In several studies, flumazenil has been reported to exert PAM effects in heterologously expressed GABAARs (De Vry & Slangen, 1985; File & Pellow, 1986; King et al., 1985; Krespan, Springfield, Haas, & Geller, 1984). In fact, flumazenil behaves as a NSAM of the BZ-binding site of α1β3γ2 and α5β3γ2 isoforms, but, like other imidazobenzodiazepines, also acts as a PAM at α2β3γ2, α3β3γ2, α4β3γ2 and α6β3γ2 isoforms (Ramerstorfer, Furtmüller, Vogel, Huck, & Sieghart, 2010).
Endozepines
2015, Advances in PharmacologyCitation Excerpt :In vitro studies have suggested a number of circuits in which endozepines are constitutively expressed and physiologically active, as evidenced by suppressive effects of FLZ on GABA-mediated inhibition, mainly through a decrease in response duration. For example, FLZ suppresses IPSP(C)s in hippocampus (King, Knox, Dingledine, 1985; Krespan, Springfield, Haas, & Geller, 1984) and in neocortical neuronal cultures (Vicini et al., 1986). FLZ has been shown to suppress inhibition in dentate gyrus granule cells in the pilocarpine model of temporal lobe epilepsy (Leroy, Poisbeau, Keller, & Nehlig, 2004) and to suppress inhibition in layer II/III neocortical pyramidal neurons (Ali & Thomson, 2008).
Electrophysiological evidence for agonist properties of flumazenil, a benzodiazepine receptor antagonist, in rat hippocampus slices
1997, Journal of the Neurological SciencesInfluences of gender, gonadectomy 5 and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats
1992, Brain Research BulletinHigh affinity ligands for 'diazepam-insensitive' benzodiazepine receptors
1992, European Journal of Pharmacology: Molecular Pharmacology