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The long-term effect of maternal dietary protein restriction on 5-HT<inf>1A</inf> receptor function and behavioral responses to stress in adulthood
2018, Behavioural Brain ResearchCitation Excerpt :Our data do suggest that there are sex differences related to hippocampal 5-HT and 5-HIAA content in weanling offspring, independent of maternal diet. Greater maternal dietary protein restriction (6% calories from protein) before and during pregnancy causes wide-spread alterations in the central serotonergic system, including diminished arborization of serotonin neurons of the dorsal raphe [46], reduced serotonergic fiber density in the hippocampus of adult rat offspring [47], decreased hippocampal 5-HT release in response to median raphe stimulation [48]. The region-specific and sex-specific deficit in hippocampal 5-HT1A receptor function observed in weanling female offspring of dams fed the low protein diet during pregnancy persisted into adulthood.
Ontogeny and regulation of the serotonin transporter: Providing insights into human disorders
2011, Pharmacology and TherapeuticsCitation Excerpt :Prenatal malnourishment impinges heavily on the serotonergic system in brain (Resnick & Morgane, 1984; Blatt et al., 1994; Mokler et al., 1999, 2003). These results include diminished growth and arborization of 5-HT neurons in the dorsal raphe nucleus (DRN) (Díaz-Cintra et al., 1981; Blatt et al., 1994; Cintra et al., 1997a, 1997b) and decreased 5-HT nerve terminals in hippocampus as indexed by reduced 5-HT1A receptor expression (Blatt et al., 1994). SERT expression is, not surprisingly, affected by nutritional status during fetal and early postnatal development.
Classical maple syrup urine disease and brain development: Principles of management and formula design
2010, Molecular Genetics and MetabolismStress-induced changes in extracellular dopamine and serotonin in the medial prefrontal cortex and dorsal hippocampus of prenatally malnourished rats
2007, Brain ResearchCitation Excerpt :Protein malnutrition has been shown to alter brain development in a number of ways. A clear and continuous finding in prenatally malnourished animals has been the alterations in the serotonergic systems of the brain (Blatt et al., 1994; Díaz-Cintra et al., 1981; Galler et al., 1996; Miller et al., 1977; Mokler et al., 1999, 2003; Morgane et al., 2002, 2003; Resnick and Morgane, 1984). Neuroanatomical findings by our group have shown diminished growth and arborization of serotonin neurons of the dorsal raphé nucleus (Blatt et al., 1994; Cintra et al., 1997; Díaz-Cintra et al., 1981).
Altered serotonergic function of dorsal raphe nucleus in perinatally protein-deprived rats: Effects of fluoxetine administration
2006, European Journal of PharmacologyModulation of 5-HT release in the hippocampus of 30-day-old rats exposed in utero to protein malnutrition
2003, Developmental Brain Research
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S. Di´az-Cintra and L. Cintra on leave from Depto. de Fisiologi´a, Instituto de Investigaciones Biome´dicas, UNAM, Universidad Nacional Auto´noma de Me´xico, Ciudad Universitaria, Me´xico, 20, D.F.