Elsevier

Brain Research

Volume 204, Issue 1, 5 January 1981, Pages 87-101
Brain Research

Norepinephrine depletion alters cerebral oxidative metabolism in the ‘active’ state

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Summary

Unilateral chemical lesion of the nucleus locus coeruleus in rats produced unilateral depletion of ipsilateral cortical norepinephrine. Norepinephrine depletion was not associated with changes in ‘resting’ metabolic balance of the cerebral cortex, as determined by in situ reflection spectrophotometry of the redox state of cytochrome oxidase. Norepinephrine depletion, however, caused slowing of the transient metabolic response to sudden increases in energy demand produced by direct cortical electrical stimulation. The effect was apparent in the redox state of both cytochrome oxidase and NAD, the latter being measured, also in situ, by reflection microfluorometry. These results demonstrate that norepinephrine has a role in modulating the response to increased metabolic demand in the corebral cortex. Norepinephrine may mediate its effect by potentiating Na+, K+-ATPase or through its effects on vascular reactivity, or both.

References (40)

  • SchwartzW.J.

    6-hydroxydopamine lesions of rat locus ceruleus alter brain glucose consumption, as measured by the 2-deoxy-d-[14C]glucose tracer technique

    Neurosci. Lett.

    (1978)
  • SharmaV.K. et al.

    Locus ceruleus lesion and chronic reserpine treatment: effects on adrenergic and cholinergic receptors in cerebral cortex and hippocampus

    Exp. Neurol.

    (1979)
  • SylviaA.L. et al.

    The effect of age and lung pathology on cytochrome a, a3 redox levels in rat cerebral cortex

    Brain Research

    (1978)
  • SylviaA.L. et al.

    Effects of age on brain oxidative metabolism in vivo

    Brain Research

    (1979)
  • Avi-DorJ.J. et al.

    Fluorescence of pyridine nucleotides in mitochondria

    J. biol. Chem.

    (1962)
  • ChanceB. et al.

    Intracellular oxidation-reduction in vivo

    Science

    (1962)
  • ChanceB. et al.

    Changes in fluorescence in a frog sartorius muscle following a twitch

    Nature (Lond.)

    (1959)
  • ChanceB. et al.

    The respiratory chain and oxidative phosphorylation

    Advanc. Enzymol.

    (1956)
  • De La TorreJ.C. et al.

    Effects of locus coeruleus stimulation on cerebral blood flow in selected brain regions

    Acta neurol. scand.

    (1977)
  • FooteS.L. et al.

    Activity of norepinephrine-containing locus ceruleus neurons in the unanesthetized squirrel monkey

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