Elsevier

Brain Research

Volume 39, Issue 1, 14 April 1972, Pages 245-251
Brain Research

Climbing fiber activation of Purkinje cells in the flocculus by impulses transferred through the visual pathway

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Cited by (116)

  • Neurophysiology of the optokinetic system

    2022, Progress in Brain Research
    Citation Excerpt :

    Clearly more work is needed to clarify these pathways and work out their dynamics, especially in the primate. The first pathway discovered was the one through the inferior olive and climbing fibers (Maekawa and Simpson, 1972, 1973) since this was essential to Ito's theory of motor learning in the cerebellum (see chapter “Plasticity and repair of the vestibulo-ocular reflex” by Robinson) and this tended to overshadow mossy fiber pathways. Nevertheless, Kyojimaekawa et al. (1975) and Maekawa and Takeda (1976) demonstrated mossy-fiber inputs to the cerebellum following electrical stimulation of the optic pathways in the rabbit, and a functional driving of simple spikes in floccular Purkinje cells due to retinal image slip has been demonstrated by Ghelarducci et al. (1975) and Barmack (1979), also in the rabbit.

  • Neural Circuits of Inputs and Outputs of the Cerebellar Cortex and Nuclei

    2021, Neuroscience
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    Kyoji Maekawa worked with John Simpson who joined Ito’s group as a postdoctoral researcher, and they looked for visual input to the flocculus. Finally, they showed that retinal image slip modulated activity of climbing fibers in the rabbit flocculus (Maekawa and Simpson, 1972, 1973). The retinal slip climbing fiber pathway to the flocculus was an amazing finding, because this climbing pathway via the nucleus of optic tract (NOT) had not been described before by neuroanatomists.

  • Adaptive processing in electrosensory systems: Links to cerebellar plasticity and learning

    2008, Journal of Physiology Paris
    Citation Excerpt :

    Accordingly, climbing fiber-induced LTD at parallel fiber synapses is often viewed as a candidate mechanism for supervised learning in the brain (Knudsen, 1994). Though the exact nature of signals conveyed by climbing fibers is still a matter of debate, the idea that climbing fibers signal errors or a need to alter motor output is supported both by studies of learning in the VOR—where climbing fibers signal retinal slip (Maekawa and Simpson, 1972) and classical eyeblink conditioning—where climbing fibers signal the unconditioned stimulus (Mauk et al., 1986; Steinmetz et al., 1989). In the case of eyeblink conditioning, climbing fiber responses to the unconditioned stimulus decrease as learning proceeds and the need for changes in performance lessens (Sears and Steinmetz, 1991; Hesslow and Ivarsson, 1996; Kim et al., 1998).

  • The accessory optic system: Basic organization with an update on connectivity, neurochemistry, and function

    2006, Progress in Brain Research
    Citation Excerpt :

    The first evidence for the inhibitory nature of the AOS–NOT interconnections came from microelectrode studies in the rabbit. Maekawa and Simpson (1972) showed that electrical stimulation of the MTN and adjacent VTRZ in rabbit inhibited the transmission of visual impulses from the optic chiasm through the NOT to the IO and cerebellar flocculus. Similarly, neurons in the NOT of rat are strongly inhibited by electrical stimulation of the MTN (van der Togt and Schmidt, 1994; Schmidt et al., 1998).

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