Original articleGenetic heterogeneity may in part explain sex differences in the familial risk for schizophrenia
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Cited by (17)
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
2022, Biological PsychiatryNeuropsychiatric Features in Primary Mitochondrial Disease
2016, Neurologic ClinicsCitation Excerpt :However, delineation of the exact genetic cause of schizophrenia remains elusive, but is likely multifactorial in nature. There are multiple pieces of evidence to suggest that mitochondrial dysfunction could be involved in the pathophysiology of schizophrenia256,257: (1) alterations in mitochondrial morphology, brain energy metabolism, and enzymatic activity of the respiratory chain in patients with schizophrenia, suggestive of mitochondrial dysfunction,258,259 (2) the rates of schizophrenia are higher among relatives of female patients compared with relatives of male patients, implying possible maternal inheritance and a role of mtDNA,257,260–270 (3) lower marriage rates and offspring production in probands with schizophrenia, suggesting its persistence could be explained only if genetic susceptibility variants are transmitted by mtDNA in female siblings,271–280 (4) major psychiatric disorders in adult patients with mitochondrial disease,256,281,282 and (5) sequence variants in the mitochondrial genome found in patients with schizophrenia.147,162,163,228,229,233,283–285 Studies of mitochondrial structure and function in patients with schizophrenia have provided evidence for mitochondrial dysfunction in the etiology of the disorder.
The genetics of sex differences in brain and behavior
2011, Frontiers in NeuroendocrinologySchizotypal, schizoid and paranoid characteristics in the biological parents of social anhedonics
2010, Psychiatry ResearchCitation Excerpt :This finding might be understood in the context of increasing evidence that the familial transmission of schizophrenia may be sex-linked in some fashion. For example, the first-degree relatives of female patients with schizophrenia have shown a higher incidence of schizophrenia and psychotic disorders compared to male patients, who tend to have first degree relatives with a higher incidence of Cluster A personality disorders and more severe flat affect (Goldstein et al., 1990, 1995). While the present study is unable to examine the differential parental contribution to proband psychopathology in a systematic way, the finding that fathers of individuals high in social anhedonia had high rates of Cluster A disorders is an intriguing result that requires replication.
Sex differences in symptoms of psychosis in a non-selected, general population sample
2003, Schizophrenia Research
This study was supported, in part, by an NIMH grant MH42604 to JMG and MTT, and, in part, by an NIMH Scientist Development Award (K21 MH00976) to JMG.