The role of Pi in the control of glycolysis in ascites tumor cells

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Abstract

Intracellular Pi has been shown to be an important factor in the control of glycolysis in Ehrlich ascites tumor cells (1–5). Glyceraldehyde-3-P dehydrogenase was then the only glycolytic enzyme known to be influenced by Pi. However, recent reports have indicated that Pi may have other important effects on glycolytic systems. Thus, in cell-free systems, Passonneau and Lowry (6) as well as Mansour (7) showed that Pi may activate phosphofructokinase by counteracting the inhibitory effect of high ATP concentrations; Rose etal (8) have reported that Pi may partially relieve the G-6-P inhibition of hexokinase in red blood cells. This information has been applied to the examination of intact ascites tumor cells in order to define more precisely the point of action of intracellular Pi in the control of glycolysis.

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