Intramolecular hydrogen bonding in cardiolipin
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Cited by (52)
The ionization properties of cardiolipin and its variants in model bilayers
2016, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The difference in these two curves further confirms that the phosphates of TOCL behave as strong acids with low pKa values. In the structural model proposed to stabilize a higher pK2 for the CL headgroup, the secondary hydroxyl of the central glycerol plays a critical role as a hydrogen bond donor to the ionized phosphate and as a hydrogen bond acceptor for the phosphate that remains protonated at higher pH [49,50] (Fig. 1B). To test the potential role of this hydroxyl group in our system, we analyzed the pH-dependence of the ζ potential of vesicles containing 20 mol% dCL, which lacks this functional group (Fig. 3C, closed circles, solid line).
Cardiolipin containing liposomes are fully ionized at physiological pH. An FT-IR study of phosphate group ionization
2014, Vibrational SpectroscopyA mitochondrial late embryogenesis abundant protein stabilizes model membranes in the dry state
2010, Biochimica et Biophysica Acta - BiomembranesThe physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes
2009, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :This observation raises issues about the possible source of the hydrogen-bonding donor groups and is particularly relevant to the structural considerations discussed in the preceding section. As noted above, the impaired flexibility of the headgroup glycerol and resultant diminution of the hydrogen-bonding reach of the headgroup hydroxyl group, suggest that inter-molecular hydrogen-bonding to neighboring phosphate groups is highly unlikely within a lipid bilayer membrane, a suggestion consistent with the insensitivity of phosphate O-P-O asymmetric stretching frequencies to the changes in lipid packing density occurring at the Lc/Lβ and Lβ/Lα phase transitions of TMCL, and with the observation that similar frequencies are observed in hydrated bilayers composed of 2′-deoxy-TPCL, in which the headgroup hydroxyl group is replaced by hydrogen [45]. However, the apparent insensitivity of phosphate O-P-O asymmetric stretching frequencies to changes in bilayer structural organization is also compatible with the existence of an intra-molecular, headgroup glycerol-to-phosphate hydrogen bond which persists in all three lamellar phases of the lipid.
Monitoring the redox and protonation dependent contributions of cardiolipin in electrochemically induced FTIR difference spectra of the cytochrome bc<inf>1</inf> complex from yeast
2009, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :The curves were fitted with the program Origin 5.0 (OriginLab Corporation, Northampton). Infrared spectra of lipids have been studied for many decades and the infrared spectroscopic properties are known to be easily influenced by the degree of hydration, the structural arrangement, specific hydrogen bonding interactions or protonation states [13,14,47,48]. For a clearer analysis of the contributions expected for the cardiolipin in the yeast cytochrome bc1 we first studied these effects with cardiolipin alone.
Issued as NRCC publication No. 32291.
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