Pharmacology of calcium antagonists
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Cited by (41)
In-situ gel of nifedipine for preeclampsia: Optimization, in-vitro and in-vivo evaluation
2019, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Among the various antihypertensive drugs available in the market literature study reveals that slow acting nifedipine is the safe antihypertensive drug for the treatment of preeclampsia [9–11]. Nifedipine is a calcium-channel blocking agent of the dihydropyridine type that is mainly used in the treatment of angina pectoris and systemic hypertension [12]. It is also used as second line treatment for preeclampsia and premature labor.
Comparison of dissolution profiles obtained from nifedipine extended release once a day products using different dissolution test apparatuses
2009, European Journal of Pharmaceutical SciencesValidation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates
2009, Journal of Pharmacological and Toxicological MethodsDiscovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95
2008, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :The observation of a greater efficacy with time was further explored by continuous presence of the drug in experiments comparing RESPIR 4-95 and the voltage operated calcium channel antagonist nifedipine. It is well established that calcium is necessary for contraction in smooth muscle fibers and that voltage operated l-type calcium channel antagonists, such as verapamil or nifedipine, can relax many types of smooth muscle effectively [11]. However, it has also been shown that airway smooth muscle is unexpectedly insensitive to the relaxing effect of this type of substances [12,13], which has led to the conclusion that airway smooth muscle has other types of calcium channels that are mainly responsible for calcium entry [14].
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia
1999, European Journal of PharmacologyCurrent status of calcium channel blockers
1994, Current Problems in Cardiology