Elsevier

The Lancet

Volume 355, Issue 9222, 24 June 2000, Page 2259
The Lancet

Dissecting Room
The Nobel Chronicles

https://doi.org/10.1016/S0140-6736(05)72762-8Get rights and content

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    Heterotrimeric G proteins play a key role in mediating diverse intracellular signal transduction in response to GPCRs activation by ligands [1–3]. The Nobel Prize in Physiology or Medicine was given to Alfred G. Gilman and Martin Rodbell in 1994 for their great discovery of a significant role of G proteins in regulating cellular function [4,5]. The GPCRs are grouped into three major family of classes based on the primary sequence similarity including class A (Rhodopsin receptor family), class B (Secretin receptor family) and class C (Glutamate receptor family).

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