Mini Focus Issue: Heart Failure With Preserved Ejection FractionState-of-the-Art PaperLeft Ventricular Amyloid Deposition in Patients With Heart Failure and Preserved Ejection Fraction
State-of-the-Art Paper
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Key Words
aging
amyloid
autopsy
diastole
heart failure with preserved ejection fraction
mass spectrometry-based proteomics
transthyretin
Abbreviations and Acronyms
EF
ejection fraction
HF
heart failure
HFpEF
heart failure with preserved ejection fraction
ICD
International Classification of Diseases
LV
left ventricle
SAB
sulfated Alcian blue
SSA
senile systemic amyloidosis
TTR
transthyretin
WFDM
whole-field digital microscopy
wtTTR
wild-type transthyretin
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The National Institutes of Health and the Mayo Clinic supported this study (grants #HL 72435, #HL 55502 and UL1 TR000135) and/or the investigators (grants #U01HL 84907 and #PO1HL 76611 to Dr. Redfield; T32-HL07111 to Dr. Mohammed). Dr. Mohammed is a heart failure clinical research network skills development fellow (U01HL 84907). A grant from FoldRx, a fully owned subsidiary of Pfizer, provided funds for technician support and mass spectrometry–based proteomics characterization. Dr. Grogan is an employee of FoldRx and has stock options. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Dr. Mohammed and Mr. Mirzoyev contributed equally to this work.
Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.