Cancer Letters

Cancer Letters

Volume 356, Issue 2, Part A, 28 January 2015, Pages 273-280
Cancer Letters

Mini-review
Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways

https://doi.org/10.1016/j.canlet.2014.02.026Get rights and content
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Abstract

The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal tract that may increase susceptibility to cancer. The colonic environment appears to play a role in the development of colon cancer, which is influenced by the human metabolic lifestyle and changes in the gut microbiome. Studying metabolic changes at the cellular level in cancer be useful for developing novel improved preventative measures, such as screening through metabolic breath-tests or treatment options that directly affect the metabolic pathways responsible for the carcinogenicity.

Keywords

Colorectal cancer
Diet
Microbiota
Butyrate
Mitochondria
Energy metabolism

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