Antifungal activity of substituted aurones
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Acknowledgements
The authors acknowledge support from Middle Tennessee State University and the Tennessee Center for Botanical Medicinal Research.
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2022, Dyes and PigmentsCitation Excerpt :Although they have a very limited presence in nature, interest in these flavonoids has been growing steadily in the past few years mostly due to their importance in medicinal chemistry [1,2]. Aurones display a wide variety of biological activities, including anticancer [3,4], antibacterial [5], antifungal [6], antimalarial [7], antileishmanial [8], anti-Alzheimer [9,10], anti-inflammatory [11] and antioxidant [12]. More recently, aurones have shown great potential to be used as chemical sensors and fluorescent labels or probes in biological and medical fields.
Recent advances on synthesis and biological activities of aurones
2021, Bioorganic and Medicinal ChemistryCitation Excerpt :Moreover, the H1N1 neuraminidase inhibition assay demonstrated that the compound 73 (4-methoxyflavone) had the lowest EC50 of 9.36 nM and IC50 of 8.74 μM respectively. In 2017, a series of aurones analogues were synthesized and evaluated for in vitro antifungal activity against Candida spp by Sutton.30 As shown in Fig. 7, two aurones analogues 74 and 75 displayed excellent activity with IC50 values below 20 μM against three species of Candida.
3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
2020, HeliyonCitation Excerpt :Aurones (2-arylidenebenzofuran-3(2H)-ones) (Figure 1), and azaaurones (2-araylideneindol-3(2H)ones) (Figure 2), belong to the flavonoid family containing an exocyclic double bond. Aurones have been reported to have important biological activities [8, 9], including anticancer [10, 11], antimicrobial [12], antileishmanial [13], anti-alzheimer [14] antiparasitic [15], antifungal [16] and anti-inflammatory [17] activity. In a particular way, aurones and azaaurones have shown a high antimalarial activity because they act as dual-stage antimalarial agent, i.e. they are capable of inhibiting exoerythrocytic and intraerythrocytic stages [18].
Catalytic and metal-free intramolecular hydroalkoxylation of alkynes
2019, Tetrahedron LettersCitation Excerpt :Moreover, they are useful intermediates for the synthesis of important biomolecules subunits such as C-glycosides [2a,b] or spirodiketal [2c]. Early strategies for their synthesis relied on the olefination of parent lactones or isomerisation of endocyclic enol ethers [3]. Intramolecular hydroalkoxylations of alkynes represent a straight and atom-economical alternative to construct such oxygenated heterocycles, that could be promoted by numerous metals.
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