Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Promoter paperMolecular cloning and analysis of the 5′-flanking region of the human bone morphogenetic protein-6 (BMP-6)
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Cited by (17)
Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors
2016, GeneCitation Excerpt :PATCH software was unable to identify any TATA or CAAT consensus sequences upstream the TSS of gilthead seabream bmp2. TATA-less promoters, also known as dispersed promoters, are very common in vertebrate genes (Barrett et al., 2013; Gagniuc and Ionescu-Tirgoviste, 2012) and several BMP genes have been reported to have TATA-less promoters (Hino et al., 1996; Kawai and Sugiura, 2001; Shore et al., 1998; Simon et al., 2002; Tamada et al., 1998), including human and mouse BMP2 genes (Ghosh-Choudhury et al., 2001; Sugiura, 1999). A survey of other BMP2 genes (i.e. zebra finch, spotted gar, zebrafish and fruit fly; Fig. 1) failed to identify TATA boxes upstream the TSS, suggesting that the presence of TATA-less promoters in BMP2 genes is a common feature.
BMP-2 modulates expression of other growth factors in a rat fracture healing model
2014, Journal of Applied BiomedicineCitation Excerpt :However, the reductions in BMP-6 mRNA levels at the later times may reflect alterations in the healing response and differential cell populations within the callus. Promoters for the human BMP-2, BMP-4, and BMP-6 genes have similar structures suggesting that any differential regulation of BMP-6 mRNA levels may be occurring via a post-transcriptional mechanism (Tamada et al., 1998). The significant increase in BMP-7 mRNA levels at day 21 is unlikely caused by a direct effect of rhBMP-2.
BMP-6 and mesenchymal stem cell differentiation
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