Biochemical and Biophysical Research Communications
Identification of the full-length coding sequence for human galactosyltransferase (β-N-acetylglucosaminide: β1,4-galactosyltransferase)
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2010, Biochimica et Biophysica Acta - Molecular Basis of DiseaseDual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines
2008, Experimental Cell ResearchCharacterization of recombinant fusion constructs of human β1,4-galactosyltransferase 1 and the lipase pre-propeptide from Staphylococcus hyicus
2008, Journal of Molecular Catalysis B: EnzymaticExpression of Specific Carbohydrates by Transfection with Carbohydrate Modifying Enzymes
2006, Methods in EnzymologyThe stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity
2004, Journal of Biological ChemistryCitation Excerpt :The stem region of GlcNAcTI was shown to be involved in heterodimerization with mannosidase II, an enzyme that acts in the same pathway of N-linked glycan maturation, although disruption of the protein-protein interaction did not compromise Golgi localization (40, 41). Stem domains can also provide sites of proteolysis; there are several reports of secreted catalytic domains of glycosyltransferases (38, 42-45) and sulfotransferases (46, 47) in physiologically relevant systems. It has been speculated that proteolysis within the stem domain and concomitant release of the catalytic domain might be a mechanism of down-regulating cellular activity (38).
Molecular cloning and functional characterization of a lepidopteran insect β4-N-acetylgalactosaminyltransferase with broad substrate specificity, a functional role in glycoprotein biosynthesis, and a potential functional role in glycolipid biosynthesis
2004, Journal of Biological ChemistryCitation Excerpt :To date, we are unaware of any structural evidence that LacDiNAc has been found in the N-glycans of any recombinant glycoprotein produced in baculovirus-infected T. ni cells or larvae. In fact, considering that the expression of most or all host cell genes is repressed during baculovirus infection (96), and that β4-N-acetylgalactosaminyltransferase activity is dramatically reduced during baculovirus infection (30), it seems rather unlikely that LacDiNAc will occur in recombinant N-glycoproteins produced using the baculovirus expression system. It is interesting to consider in retrospect that we actually intended to isolate an insect β4-galactosyltransferase cDNA in this study.