Sea wasp (Chironex fleckeri) antivenene: Neutralizing potency against the venom of three other jellyfish species
References (11)
Extraction of cnidarian venom from living tentacle
- et al.
Immunity to the venom of the sea wasp
Toxicon
(1968) - et al.
Some immunological aspects of sea nettle toxins
Toxicon
(1971) - et al.
Toxic material from the tentacles of the cubomedusan Chironex fleckeri
Toxicon
(1971) - et al.
Dermatonecrotic properties of extracts from the tentacles of the cnidarian Chironex fleckeri
Toxicon
(1969)
Cited by (26)
The pathology of Chironex fleckeri venom and known biological mechanisms
2020, Toxicon: XCitation Excerpt :It was hoped that treatment with antivenom would prevent effects seen in severe envenomation by neutralising causative toxins in the venom. The Commonwealth Serum Laboratories (CSL) first produced C. fleckeri antivenom in the 1970s using hyper-immunized sheep (Baxter and Marr, 1974; Currie and Jacups, 2005) and continue to produce antivenom. However, C. fleckeri antivenom efficacy has been called into question through data from animals and patients (Currie, 2003; Currie and Jacups, 2005; Endean and Sizemore, 1988; Konstantakopoulos et al., 2009; Ramasamy et al., 2003; Winter et al., 2007, 2009).
A pharmacological investigation of the venom extract of the Australian box jellyfish, Chironex fleckeri, in cardiac and vascular tissues
2012, Toxicology LettersCitation Excerpt :They demonstrated that this venom is an allosteric modulator of such channels, suggesting that sensory nerve toxicity may also contribute to the pathogenesis of this envenomation. Box jellyfish antivenom has been produced since 1971 and is indicated for use after a serious box jellyfish envenomation where there is risk of cardiovascular collapse (Baxter and Marr, 1969, 1974; Winkel et al., 2003). Although antivenom use is associated with survival, there is still much debate surrounding its efficacy (Bailey et al., 2003; Ramasamy et al., 2004).
Biochemical and molecular characterisation of cubozoan protein toxins
2009, ToxiconCitation Excerpt :Biochemical characterisation of cubozoan venom proteins is further complicated by issues such as inaccurate identification of box jellyfish species and intra-species variations in venom composition. For example, biochemical studies were undertaken on an Australasian box jellyfish, which at the time of the experiments was reported as C. quadrigatus (e.g. Keen, 1971; Freeman and Turner, 1972; Baxter and Marr, 1974), but is now known as a new species within a different genus (C. bronzie; Gershwin, 2006). In terms of intra-species variations, recent studies using nematocysts isolated from the bell and tentacles of C. barnesi revealed that the protein profile of bell nematocyst venom differed from that of tentacle nematocyst venom (Underwood and Seymour, 2007).
A cell-based assay for screening of antidotes to, and antivenom against Chironex fleckeri (box jellyfish) venom
2009, Journal of Pharmacological and Toxicological Methods