Controversies in Rh prophylaxis: Who needs Rh immune globulin and when should it be given?
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Missed anti-D immune globulin administration to postpartum patients in 2 health systems: an unrecognized patient safety risk
2022, AJOG Global ReportsCitation Excerpt :Fetal erythrocyte hemolysis may cause severe fetal anemia which, if untreated, leads to heart failure, hydrops fetalis, and intrauterine fetal demise.1 Delivery commonly results in maternal exposure to fetal blood and, in the era before the routine administration of anti-D prophylaxis, the risk of alloimmunization to those who delivered a D-positive infant was approximately 16%.2 Anti-D immune globulin (RHIG), a human plasma derivative, can prevent alloimmunization in Rh-negative patients who deliver Rh-positive infants.
Immunohematologic aspects of alloimmunization and alloantibody detection: A focus on pregnancy and hemolytic disease of the fetus and newborn
2020, Transfusion and Apheresis Science“Provoked” feto-maternal hemorrhage may represent insensible cell exchange in pregnancies from 6 to 22 weeks gestational age
2019, ContraceptionCitation Excerpt :Disruption of the feto-maternal interface increases the likelihood of passage of fetal red blood cells (FRBCs) from fetus to mother [2,3]. While the majority of these sensitizing events occur in late pregnancy or at delivery, sensitization can occur earlier if sufficient numbers of fetal cells pass and are detected by the maternal immune system [4,5]. The absolute threshold for sensitization is unknown but likely influenced by both fetal and maternal factors.
Haemolytic Disease of the Fetus and Newborn
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2018, Clinical Principles of Transfusion Medicine